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[Shin-Min Joon, Edaily Reporter] On October 21 shares of HansBiomed, HLB and NIBEC stood out in the South Korean biopharmaceutical stock market each recording double digit gains compared to the previous trading day.
HansBiomed¡¯s stock rose on growing momentum for its extracellular matrix (ECM) based ski Åë´ëȯ n booster. HLB gained after news broke that its liver cancer drug could expand its treatment scope from advanced to surgically resectable cases as reported in an international medical journal. Meanwhi Áֺκü¸¥´ëÃâ le NIBEC saw its shares climb on expectations for the U.S. expansion of its next generation periodontal tissue regeneration material.
HansBiomed stock tr °³ÀÎȸ»ýÀΰ¡Àü´ëÃâ end on Oct 21.(Image=MP Doctor)
HansBiomed Soars on ECM Skin Booster Outlook
HansBiomed shares surged 16.74% to 27,200 won on the back ´ëÃâ¿ø±Ý»óȯ of growing expectations for its extracellular matrix (ECM) skin booster Celluderm. The company a bioengineering firm focused on human tissue transplants and medical devices has positioned Celluderm a °³ÀÎÆÄ»êÀÚ´ëÃâ°¡´ÉÇѰ÷ s a next generation skin rejuvenation product.
Unlike traditional skin boosters that stimulate collagen indirectly Celluderm utilizes human derived acellular dermal matrix (hADM) to directly replenish collagen. Designed with ultra fine 75§ particles Celluderm ensures even and abundant collagen delivery.
HansBiomed the first domestic company to establish a tissue bank in Korea, is recognized for its expertise and reliability in tissue transplantation. Its proprietary processing technology minimizes immune-reactive agents, enhancing biocompatibility and reducing side effects.
The company has expanded its target number of domestic hospitals adopting Celluderm to 4000. As a result it has revised its 2025 sales goal from 3 to 4 billion won to between 25 and 30 billion won.
HansBiomed also plans to expand exports to Japan and China. In Japan, where regulatory hurdles are minimal, sales are expected to begin soon. In China, the company is in the process of obtaining medical device approval.
A company representative noted ¡°The upward revision of our sales target has likely bolstered investor sentiment. Celluderm is not just a skin enhancer it aims to fundamentally rejuvenate the skin using ECM technology.¡± They added ¡°With Celluderm Hans Biomed seeks to pioneer a new category of skin boosters globally.¡±
HLB Gains on Expanded Use Case for Liver Cancer Drug
HLB¡¯s stock jumped 11.17% to 45,800 won after announcing new clinical trial results supporting broader applications for its liver cancer therapy. The combination of its targeted anti cancer drug Rivoceranib with Hengrui¡¯s immunotherapy Camrelizumab has shown promising results not only for advanced hepatocellular carcinoma (HCC) but also for patients eligible for surgery.
The findings recently published in The Lancet demonstrated that the combination therapy more than doubled event free survival (EFS) to 42.1 months compared to 19.4 months for surgery alone. Major pathological response (MPR) rates were also significantly higher at 35% versus 8%.
The phase 2/3 trial conducted at 16 hospitals across China enrolled 294 patients with resectable HCC who had moderate to high risk of recurrence. Patients were randomly assigned to surgery alone or to receive the combination therapy before and after surgery.
Serious treatment related adverse events (Grade 3 or higher) occurred in 38% of patients receiving the combination therapy consistent with known safety profiles for such treatments.
An HLB official said ¡°This is the first time a global phase 3 study has confirmed the efficacy of combining immunotherapy with targeted therapy in both pre and post operative settings.¡±
They added, ¡°This suggests a paradigm shift in liver cancer treatment beyond surgical monotherapy.¡±
Hengrui plans to resubmit its New Drug Application (NDA) to the U.S. FDA between December 2025 and January 2026. Depending on the classification (Class 1 or 2) the FDA is expected to issue a decision within 2 to 6 months of submission.
NIBEC Eyes U.S. Market with Next Gen Periodontal Regenerative Material
NIBEC¡¯s share price rose 12.64% to 41,450 won on optimism surrounding its U.S. expansion strategy. The company is seeking FDA approval for its next generation decellularized biomaterial, designed to support gum tissue regeneration following tooth extraction and bone grafting procedures.
NIBEC recently showcased the material at the American Academy of Periodontology (AAP) 2025 in Toronto. This marked its first official participation and was part of a broader strategy to build clinical credibility and market presence in the U.S.
The company aims to establish a U.S. foothold through collaboration with key opinion leaders (KOL) in regenerative medicine. NIBEC also plans to present its BBB (blood brain barrier) shuttle platform at the Central Nervous System Drug Delivery Conference on December 10.
Earlier this year, NIBEC secured a licensing deal worth $435 million (595.3 billion won) with a U.S.based biopharma company.
A NIBEC spokesperson stated ¡°Our participation in the AAP event is a strategic step to build global clinical trust in periodontal regeneration adding that this effort is expected to contribute significantly to future revenue growth.¡±
½Å¹ÎÁØ (adonis@edaily.co.kr)